Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements

摘要

Deg of mammalian donor systemic inflammation is determined from a sample of donor anticoagulated whole blood A sample of the blood is drawn from a donor into a transparent tube (2) contg. an elongated float (4). The sample is centrifuged in the tube. The amount of fibrinogen/fibrin in the blood sample in the tube is measured. A haematocrit or haemoglobin value for the blood sample in the tube is determined. A number I, indicative of the degree of systemic inflammation, is computed by solving equation (i) I = a(f) + b(h) + c where f is the measured fibrinogen/fibrin level in the sample; h is the determined haematocrit or haemoglobin value in the sample; and a, b and c are empirically derived constants. The numerical value of I is correlated with the deg. of mammalian donor systemic inflammation.