4-fluorobiphenyl derivatives

摘要

A 4-fluorobiphenyl derivative of formula (I), which is useful as a cholesterol lowering agent or a lipid lowering agent because of its strong inhibitory effect on HMG-CoA reductase), and which is also useful as an intermediate for producing the above-mentioned cholesterol lowering agent or lipid lowering agent: <IMAGE> (I) wherein A is a omega -oxycarbonyldihydroxybutyl group, a tetrahydropyranyl group, a omega -oxycarbonyl-3-oxobutyl group, a formyl group, or a cyano group; R1 is a halogen atom, an alkyl group, or a group represented by R5O-, wherein R5 is a hydrogen atom, or an alkyl group; R2 is a hydrogen atom, an alkyl group; R3 is a hydrogen atom, or an alkyl group; R5 and R2 may form a five-membered ring or a six-membered ring in combination with the oxygen atoms to which R5 and R2 are respectively bonded, and R5 and R3 may form a five-membered ring or a six-membered ring in combination with the oxygen atom to which R5 is bonded.