16-membered macrolide derivatives and process for producing the same

摘要

16-membered macrolide derivatives represented by the formula (I): <IMAGE> (I) wherein R1 represents a hydrogen atom or a COR6 group, wherein R6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R2 represents a hydrogen atom or a COR6 group, wherein R6 is as defined above; R3 represents a hydrogen atom or a COR6 group, wherein R6 is as defined above; R4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms; and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.