摘要 |
PCT No. PCT/US93/05783 Sec. 371 Date May 25, 1994 Sec. 102(e) Date May 25, 1994 PCT Filed Jun. 16, 1993 PCT Pub. No. WO93/25571 PCT Pub. Date Dec. 23, 1993.A liquid phase peptide synthetic method which uses (1) Fmoc as the protecting group for the non-side chain amino functionality, (2) ammonia, a primary or secondary amine to remove the Fmoc protecting group, and (3) substituted carbodiimide as the coupling agent for the C to N synthesis of peptides or peptide derivatives in a proper organic solvent.
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