| 摘要 |
<p>Devices are hand-held, self-contained units which are automatically actuated at the same release point in a patient's inspiratory flow cycle. Actuation of the device forces an algesic formulation (5) through a porous membrane (3) of the container (1) which membrane has pores having a diameter in the range of about 0.25 microns to 1.5 microns. The porous membrane is positioned in alignment with a surface of a channel (11) through which a patient inhales air. The flow profile of air moving through the channel is such that the flow at the surface of the channel is less than the flow rate at the center of the channel. The membrane is designed so that it protrudes outward at all times or made flexible so that when an analgesic formulation is forced against and through the membrane, the flexible membrane protrudes outward beyond the flow boundary layer (13) of the channel into faster moving air.</p> |
