发明名称 |
Production of optically active compounds |
摘要 |
A process for producing an optically active form of a compound of formula (I) <CHEM> wherein R1 represents hydrogen or a hydrocarbon group that may be substituted; R2 and R3 independently represent hydrogen, a hydrocarbon group that may be substituted, or a heteroaromatic group that may be substituted; X' represents a substituent comprising an esterified carboxyl group or an acylated hydroxyl group; ring A represents a benzene ring that may be substituted or a heteroaromatic ring that may be substituted; ring J' represents a 7- or 8-membered heterocyclic ring containing at most 3 hetero-atoms as ring-constituent members, which may have a further substituent or substituents in addition to R1, R2, R3 and X', and C* denotes a chiral carbon atom or a salt thereof, which comprises subjecting the racemic compound of the formula (I) or a salt thereof, or alternatively a racemic starting compound for synthesizing the compound of the formula (I) to enzymatically enantioselective hydrolysis to provide an optically active form thereof. |
申请公布号 |
EP0710725(A1) |
申请公布日期 |
1996.05.08 |
申请号 |
EP19950117120 |
申请日期 |
1995.10.31 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
NAKAHAMA, KAZUO;IZAWA, MOTOWO;NAGANO, YOICHI;TARUI, NAOKI;MATSUMOTO, KIYOHARU;KORI, MASAKUNI;KANAMARU, TSUNEO;NAGATA, TOSHIAKI |
分类号 |
C12P7/22;C12P17/10;C12P41/00 |
主分类号 |
C12P7/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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