发明名称 NOVEL ACID PYRAZOLE AND PYRAZOLONE DERIVATIVES FOR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS
摘要 Products of formula (I) wherein R1 and R2 are hydrogen or optionally substituted alkyl, aryl, arylalkyl or alkylaryl, R3, R4 and R5 are keto, -(CH2)n-R6, -CH=CH-(CH2)n-R6 or -C &cir& C-(CH2)n-R6, where n is 0-4 and R6 is hydroxyl, a lkoxy and aryloxy, alkylthio, arylthio, carboxy, cyano, alkyl, aryl, amino, mono- or dialkylamino, acylamino, and (a), -(NH)m-SO2-W, where m is 0 or 1, W is -NH-R7, (b), (c), (d) or -R7, R7 is hydrogen, alkyl or aryl and R8 is R7 except for hydrogen, or one of R3, R4 and R5 is hydrogen, and all the possible isomeric forms of the products of formula (I), are disclosed.
申请公布号 WO9612706(A1) 申请公布日期 1996.05.02
申请号 WO1995FR01386 申请日期 1995.10.20
申请人 ROUSSEL UCLAF;FORTIN, MICHEL;ZHANG, JIDONG 发明人 FORTIN, MICHEL;ZHANG, JIDONG
分类号 C07D231/22;C07D405/06 主分类号 C07D231/22
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