发明名称 |
BICYCLIC CARBOXAMIDES AS 5-HT1A ANTAGONISTS |
摘要 |
Bicyclic carboxamides of formula (I) and the pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists, and may be used, for example, as anxiolytics. In the formula, X represents -CR<2> = CR<2>- or -(CR<2>)q-; m represents 0, 1 or 2; n represents 0, 1 or 2; p represents 0, 1, 2 or 3, and q represents 0, 1, 2 or 3; A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups; R is a mono or bicyclic aryl or heteroaryl radical; R<1> is an aryl or aryl(lower)alkyl radical; and each R<2> is independently hydrogen or lower alkyl.
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申请公布号 |
WO9609302(A1) |
申请公布日期 |
1996.03.28 |
申请号 |
WO1995GB02001 |
申请日期 |
1995.08.23 |
申请人 |
JOHN WYETH & BROTHER LTD.;AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
CLIFFE, IAN, ANTHONY;MANSELL, HOWARD, LANGHAM;WARD, TERENCE, JAMES;NELSON, JAMES, ALBERT;SHAH, URESH, SHANTILAL;KANZELBERGER, MIRA, ANA |
分类号 |
A61K31/495;A61K31/55;A61P9/12;A61P25/18;A61P25/20;A61P43/00;C07D209/44;C07D209/52;C07D223/14;C07D295/185;C07D403/12;C07D451/02;(IPC1-7):C07D451/02;A61K31/395;C07D221/24;C07D403/04 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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