FIBROBLASTS FOR THE TREATMENT OF MUSCULAR DISORDERS

摘要

Muscular disorders such as Duchenne muscular dystrophy are alleviated by introducing dermal fibroblasts (which may be the patient's own), into the muscle. In vivo fusion of the donor cells with each other converts them into muscle cells, which produce the products of muscle-specific genes such as dystrophin and other muscle proteins. The donor fibroblasts may contain musclespecific DNA.