3-AMINOAZEPINE COMPOUND AND PHARMACEUTICAL USE THEREOF

摘要

A 3-aminoazepine compound represented by general formula (I), an optically active isomer thereof, or a pharmaceutically acceptable salt thereof, wherein Ar represents phenyl, etc.; R<1> represents hydrogen, alkyl, etc.; R<2> and R<3> represent each independently hydrogen, alkyl, -CO-R<6> (wherein R<6> represents heteroaryl, etc.), -CONH-R<7> (wherein R<7> represents phenyl, etc.), etc.; R<4> represents hydrogen, alkyl, etc.; X represents oxygen or sulfur, provided R<4> and X may be combined together to form -C(R<1><0>)=N-N= (wherein R<1><0> represents hydrogen, alkyl, etc.). This compound has CCK and gastrin antagonisms and is useful as a remedy for central nervous system diseases such as anxiety and depression and as a preventive or a remedy for pancreatic diseases and gastrointestinal ulcer. <CHEM>