N-alkyl-taurourodeoxycholic acids and their therapeutically active derivatives

摘要

The invention discloses N-alkyl-tauroursodeoxycholic acids and their pharmaceutically acceptable salts of the formula <IMAGE> wherein R is a C2-C4 alkyl group and R1 is hydrogen, an alkali metal, an alkaline earth metal or a radical of a basic amino acid. The compounds are prepared by reacting a mixed anhydride of ursodeoxycholic acid and alkyltaurine followed by percolation through two columns respectively containing a strong cationic resin in H+ form and a weakly anionic resin OH- form. The compounds are useful for the treatment of hepatic diseases.