发明名称 |
OLIGONUCLEOTIDE PRODRUGS |
摘要 |
Disclosed is an oligonucleotide prodrug comprising at least six covalently linked nucleotides, at least one of which is derivatized with a lipophilic chemical group reversibly and covalently attached to the nucleotide at a 5' phosphate, a 3' phosphate, or an internucleotidic phosphate linkage. The prodrug is reactive with a cellular or tissue enzyme which cleaves the lipophilic group from the derivatized nucleotide, thereby regenerating the parent oligonucleotide.
|
申请公布号 |
CA2199464(A1) |
申请公布日期 |
1996.03.14 |
申请号 |
CA19952199464 |
申请日期 |
1995.09.07 |
申请人 |
HYBRIDON, INC. |
发明人 |
IYER, RADHAKRISHNAN;YU, DONG;AGRAWAL, SUDHIR;DEVLIN, THERESA |
分类号 |
A61K31/70;A61K31/7088;A61P31/12;C07H21/00;C12N15/113;(IPC1-7):C07H21/00;C07J43/00 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|