O-METHYL DERIVATIVES OF AZITHROMYCIN A, PROCESS FOR THEIR PREPARATION, INTERMEDIATE FOR THEIR PREPARATION AS WELL AS THEIR USE WHEN PREPARING PHARMACEUTICAL PREPARATIONS

摘要

Vynález sa týká O-methyl-derivátů azithromycinu A obecného vzorce I, kde Ia R.sup.1.n.=R.sup.2.n.=CO.sub.2.n.CH.sub.2.n.C.sub.6.n.H.sub.5.n., R.sup.3.n.=CH.sub.3.n., R.sup.4.n.=R.sup.5.n.=H Ib R.sup.1.n.=R.sup.2.n.=CO.sub.2.n.CH.sub.2.n.C.sub.6.n.H.sub.5.n., R.sup.3.n.=R.sup.4.n.=CH.sub.3.n., R.sup.5.n.=H I.sub.c .n.R.sup.1.n.=R.sup.2.n.=CO.sub.2.n.CH.sub.2.n.C.sub.6.n.H.sub.5.n., R.sup.3.n.=R.sup.5.n.=H, R.sup.4.n.=CH.sub.3.n. Id R.sup.1.n.=R.sup.2.n.=CO.sub.2.n.CH.sub.2.n.C.sub.6.n.H.sub.5.n., R.sup.3.n.=R.sup.4.n.=R.sup.5.n.=CH.sub.3.n. Ie R.sup.1.n.=R.sup.2.n.=R.sup.4.n.=R.sup.5.n.=H, R.sup.3.n.=CH.sub.3.n. If R.sup.1.n.=R.sup.2.n.=R.sup.5.n.=H, R.sup.3.n.=R.sup.4.n.=CH.sub.3.n. Ig R.sup.1.n.=R.sup.2.n.=R.sup.3.n.=R.sup.5.n.=H, R.sup.4.n.=CH.sub.3.n. Ih R.sup.1.n.=R.sup.2.n.=H, R.sup.3.n.=R.sup.4.n.=R.sup.5.n.=CH.sub.3.n. Ii R.sup.1.n.=R.sup.4.n.=R.sup.5.n.=H, R.sup.2.n.=R.sup.3.n.=CH.sub.3.n. Ij R.sup.1.n.=R.sup.5.n.=H, R.sup.2.n.=R.sup.3.n.=R.sup.4.n.=CH.sub.3.n. Ik R.sup.1.n.=Rŕ