发明名称 |
Process for the synthesis of 9-(2-hydroxyethoxy methyl) guanine |
摘要 |
A process for the synthesis of 9-(2-hydroxyethoxy methyl) guanine in which guanine, or its salts, is reacted with 2-4 moles of hexamethyldisilazane, in the presence of an aprotic solvent and of ammonium sulfate. Thereafter, the trimethylsilyl derivative, without being isolated, is reacted with a stoichiometric quantity of an acyloxyethoxy methyl halide and hydrolyzed with aqueous sodium acetate or sodium hydroxyde to give 9-(2-hydroxyethyoxy methyl) guanine.
|
申请公布号 |
US5496945(A) |
申请公布日期 |
1996.03.05 |
申请号 |
US19940261053 |
申请日期 |
1994.06.13 |
申请人 |
SOLAR CHEMICAL S.A. |
发明人 |
BRUZZESE, TIBERIO;GUAZZI, GIUSEPPE;ROGNONI, MARCO;MARCON, GIULIANO |
分类号 |
C07D473/00;C07D473/18;(IPC1-7):C07D473/18 |
主分类号 |
C07D473/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|