| 摘要 |
PCT No. PCT/GB95/01795 Sec. 371 Date Feb. 3, 1997 Sec. 102(e) Date Feb. 3, 1997 PCT Filed Jul. 31, 1995 PCT Pub. No. WO96/04312 PCT Pub. Date Feb. 15, 1996Binding agents, such as antibodies, are described which selectively bind to the cluster-w4 polypeptide of human small cell lung carcinoma cells at a site located at and around valine-57 of the cluster-w4 polypeptide. The binding agents, either alone or linked to a reporter or effector molecule are of use in the diagnosis or treatment of human small cell lung carcinoma. Also described are peptides (A)m-(T)n-(T)o-(K)p-V-(A)q-(G)r-(G)s-(A)t-(L)u having at least one of the core structures K-V-A, T-K-V, or V-A-G for use in the identification and/or preparation of binding agents according to the invention, as diagnostic reagents, or as immunostimulants. |
