DISTAMYCIN A ANALOGUES AS ANTITUMOUR OR ANTIVIRAL AGENTS

摘要

The present invention relates to compounds of formula (I) wherein n is 0 or 1; each of X, Y, Z is independently N or CH; A is a pentatomic heteromonocyclic ring unsubstituted or substituted by a C1-C3 alkyl group; B is (a); (b); (c) or (d); and either R1 and R2 are the same and they are both a C1-C6 alkyl group unsubstituted or substituted by halogen or hydroxy; or one of R1 and R2 is hydrogen and the other is a group (e) in which m is zero or an integer of 1 to 4 and R4 is aziridinyl; cyclopropyl; a vinyl group unsubstituted or substituted in position 1 or 2 by halogen or C1-C3 alkyl; an oxyranyl group unsubstituted or substituted in position 2 by a C1-C3 alkyl or halogen; or a group (f) in which R5 and R6 are both a C1-C6 alkyl group unsubstituted or substituted by a halogen or hydroxy; provided that: a) when each of X, Y, Z is CH, then A is not thiophene or pyrrole unsubstituted or substituted by a C1-C3 alkyl group; and b) when n is 1, each of X, Y, Z is CH and R1 and R2 are the same and they are both 2-chloroethyl, then A is not 1-methylimidazole or thiazole; and the pharmaceutically acceptable salt thereof. The compounds of the invention are useful as antitumor or antiviral agents.