| 发明名称 |
Process for the preparation of fused pyridine compounds |
| 摘要 |
<p>Pyrido[2,3-d]pyrimidine compounds of formula <CHEM> wherein: R<1> is -NHCH(COOR<2>)CH2CH2COOR<3>, or OR<2> in which each of R<2> and R<3> is hydrogen or a carboxylic acid protecting group; and n has a value of from 1 to 3, are prepared through the reaction of 2,4-diamino-6(1H)-pyrimidone and an activated derivative of a dialdehyde. A typical embodiment utilizes the dinitrile.</p> |
| 申请公布号 |
EP0314280(B1) |
申请公布日期 |
1996.02.21 |
| 申请号 |
EP19880308250 |
申请日期 |
1988.09.07 |
| 申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY |
发明人 |
TAYLOR, EDWARD C.;HARRINGTON, PHILIP M. |
| 分类号 |
A61K31/505;A61P29/00;A61P31/00;A61P35/00;A61P35/02;C07D471/04;(IPC1-7):C07D471/04 |
主分类号 |
A61K31/505 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
