发明名称 |
Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells |
摘要 |
This disclosure relates to two separate and distinct inward rectifier K+ channel expression products and the the genes which encode each expression product. The IRK1 gene (SEQ. ID NO: 1) encodes an inward rectifier K+ channel and the GIRK1 gene (SEQ. ID NO: 31) encodes a G protein coupled muscarinic K+ channel. The disclosure relates to the uses of these expression products, particularly in combination with identifying physiological processes mediated by these channels, such as regulation of heartbeat and insulin release and materials modulating or blocking same.
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申请公布号 |
US5492825(A) |
申请公布日期 |
1996.02.20 |
申请号 |
US19930103445 |
申请日期 |
1993.08.06 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
JAN, LILY Y.;JAN, YUH N.;KUBO, YOSHIHIRO |
分类号 |
A61K38/00;C07K14/705;C12N15/12;(IPC1-7):C12N15/12;C12N15/63;C12N5/10;C12N1/21 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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