发明名称 |
CELLS BEARING CD4 DECOY RECEPTORS AND RELATED MOLECULES AND METHODS |
摘要 |
Disclosed is a method of treating HIV in a mammal involving administering to the mammal an effective amount of therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection. Also disclosed are cells which express these CD4 receptors and DNA and vectors encoding the receptors.
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申请公布号 |
WO9603883(A1) |
申请公布日期 |
1996.02.15 |
申请号 |
WO1995US09468 |
申请日期 |
1995.07.26 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
SEED, BRIAN;BANAPOUR, BABAK;ROMEO, CHARLES;KOLANUS, WALDEMAR |
分类号 |
C12N15/09;A01N63/00;A61K35/14;A61K38/00;A61P31/18;C07K14/725;C07K14/73;C07K19/00;C12N5/10;(IPC1-7):A01N63/00;C12P21/06;C12N15/11;C12N15/63;C12N15/85;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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