Verfahren zur Herstellung von Selegilin-Hydrochlorid
摘要
The invention concerns a process for preparing selegilin hydrochloride by reacting R-(-)-N, alpha -dimethyl-phenylethylamine with 3-bromo-1-propine, characterized in that the substances are reacted in a molar ratio of approximately 2:1 at a temperature of between 30 and 50 DEG C in a solvent mixture comprising an aromatic hydrocarbon and water without a catalyst, and the selegilin is isolated from the organic phase and converted into hydrochloride.
申请公布号
DE4432610(C1)
申请公布日期
1996.02.01
申请号
DE19944432610
申请日期
1994.09.13
申请人
KNOLL AG, 67061 LUDWIGSHAFEN, DE
发明人
OTT-DOMBROWSKI, SILVIA, 32459 PETERSHAGEN, DE;CYRUS, RICHARD, DR., 67067 LUDWIGSHAFEN, DE;SCHMIDT, JOERG, 32425 MINDEN, DE;WAIBLINGER, HANS, DR., 32547 BAD OEYNHAUSEN, DE
