| 摘要 |
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to their use in the treatment of hypertension as well as for treatment of peripheral vascular disease, congestive heart failure, disorders involving excessive smooth muscle contraction of the urinary tract such as incontinence or of the gastrointestinal tract such as irritable bowel syndrome, asthma, and hair loss and to pharmaceutical compositions containing an invention compound. The present invention discloses compounds represented by the formula (I): <IMAGE> I wherein: R1 and R2, independent from each other, are selected from the following: C1-6 perfluoroalkoxy, C1-6 perfluoroalkyl, C1-6 alkyl, C1-6 alkoxy, hydroxyl, C1-6 alkoxycarbonyl, nitro, cyano, halogen, C1-6 alkylsulfonamido, C1-6 perfluoroalkylsulfonamido, amino, C1-6 acylamino, C1-6 perfluoroacylamino, mono or di-C1-12 alkylamino, C1-6 alkylsulfonyl, C6-10 arylsulfonyl, carboxyl, C1-12 mono or di-alkylaminocarbonyl, or hydrogen; a and b together form an -O- linkage, C=O, or a direct bond: R3 and R4, independent from each other, are H or C1-6 alkyl, optionally substituted by fluorine; R5 is amino or C1-12 mono alkylamine; R6 is H, C1-6 perfluoroalkyl, C1-6 alkyl, C6-10 aryl, or mono or bicyclic heteroaryl containing 1-3 heteroatoms selected from N, O, or S.
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