INHIBITORS OF INTERLEUKIN-1 beta CONVERTING ENZYME
摘要
The present invention relates to novel classes of compounds which are inhibitors of interleukin-1 beta converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.
申请公布号
WO9535308(A1)
申请公布日期
1995.12.28
申请号
WO1995US07617
申请日期
1995.06.16
申请人
VERTEX PHARMACEUTICALS INCORPORATED
发明人
BEMIS, GUY, W.;GOLEC, JULIAN, M., C.;LAUFFER, DAVID, J.;MULLICAN, MICHAEL, D.;MURCKO, MARK, A.;LIVINGSTON, DAVID, J.