| 摘要 |
PURPOSE:To obtain a compound useful as an antifungal agent effective for therapy of dermatomycosis, visceral mycosis, etc. CONSTITUTION:This compound is represented by the formula (A is =CH-or =N-; L and M are H, a halogen; R<1> is a five-membered heterocycle or a condensed ring), or its acid adduct, e.g. 1-(2,4-difluorophenyl)-1-[4-(2,4-difluorophenyl- thiazol-2-yl]-2-(1H-1,2,4-triazol-1-yl)ethanol. This compound can be synthesized by reacting 4-(2,4-difluoro-phenyl)thiazole with 2-chloro-2',4'-difluoroacetophenone in the presence of n-butyllithium and subsequently adding and reacting 1,2,4- triazole and sodium hydride therewith. |
