PIRYDYL IMIDAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

摘要

Novel pyridyl imidazole derivatives of formula (I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity, wherein A is a straight, branched or cyclic C1-C6 alkyl or alkenyl group, OR<1> (wherein R<1> is a hydrogen, or a straight, branched or cyclic C1-C6 alkyl or alkenyl radical), or NR<2>R<3> (wherein R<2> and R<3> are independently a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical); B is a group of formula (II); D is a hydrogen; a halogen; a straight, branched or cyclic C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R<1>, COR<1>, CON(R<1>)2 or N(R<1>)2, wherein R<1> is the same as defined above; tetrazol-5-yl; a perfluoro-C1-C4 alkyl group; or N(R<1>)2, OR<1>, CO2R<1> or CON(R<1>)2, wherein R<1> is the same as defined above; E is a hydrogen; a halogen; a straight or branched C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R<1>, COR<1>, CON(R<1>)2 or N(R<1>)2, wherein R<1> is the same as defined above; a perfluoro-C1-C4 alkyl group; NO2; or N(R<1>)2 or OR<1>, wherein R<1> is the same as defined above; and n is 0 or an integer of 1 to 4.