发明名称 |
HYBRID MOLECULE OF FORMULA GM-CSF-L-EPO OR EPO-L-GM-CSF FOR HEMATOPOIETIC STIMULATION |
摘要 |
It is described a hybrid molecule of formula GM-CSF-L-EPO or EPO-L-GM-CSF useful for the stimulation of hematopoiesis, comprising GM-CSF and EPO molecules fused together by means of a linker L having a variable length of amino acids, GM-CSF and EPO molecules being either complete molecules or fragments thereof. Such hybrid molecules exhibit a higher specificity of action on erythroid differentiation if compared to that of an equimolar mixture of not-linked GM-CSF and EPO molecules. Further, the present invention describes: DNA sequences encoding such hybrid molecules, which stimulate the hematopoiesis; plasmid vectors containing the genes encoding hybrid molecules and directing their synthesis in host cells; the use of such hybrid molecules for the preparation of a pharmaceutical composition and such pharmaceutical composition useful for stimulation of hematopoiesis.
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申请公布号 |
WO9533057(A1) |
申请公布日期 |
1995.12.07 |
申请号 |
WO1995EP02011 |
申请日期 |
1995.05.26 |
申请人 |
MENARINI RICERCHE SUD S.P.A.;MELE, ANTONIO;DE SANTIS, RITA;CARLONI, CRISTINA;COSCARELLA, ANNAMARIA |
发明人 |
MELE, ANTONIO;DE SANTIS, RITA;CARLONI, CRISTINA;COSCARELLA, ANNAMARIA |
分类号 |
C12N15/09;A61K38/00;A61K38/22;A61P7/00;C07H21/04;C07K14/505;C07K14/535;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12P21/02;(IPC1-7):C12N15/62;A61K38/18;A61K38/19;C07K9/00 |
主分类号 |
C12N15/09 |
代理机构 |
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