发明名称 |
Solvent-free synthesis of 1,2:5,6-di-O-isopropylidene-3-O-3' -(N',N'-dimethylamino-n-propyl)-alpha,D-glucofuranose and 1,2:5,6-di-O-isopropylidene-3-O-heptyl-alpha,D-glucofuranose. |
摘要 |
<p>A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of: 1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base; 2) heating the mixture to a temperature sufficient to allow the mixture to react; 3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced; 4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture; 5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally, 6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups. e</p> |
申请公布号 |
GR3017070(T3) |
申请公布日期 |
1995.11.30 |
申请号 |
GR19950402198T |
申请日期 |
1995.08.09 |
申请人 |
GREENWICH PHARMACEUTICALS INCORPORATED |
发明人 |
ARORA, SUDERSHAN, K. |
分类号 |
C07H1/00;C07H9/04;C07H15/04;(IPC1-7):C07H15/04 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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