| 摘要 |
The present invention relates to assays for the identification of compounds that block palmitylation of influenza virus HA and inhibit virus assembly. In another aspect of the invention, the compounds which inhibit virus assembly, infection and/or replication and which demonstrate a good therapeutic index may be used to treat influenza infection. The invention is based, in part, on the Applicant's discovery that mutations of palmitylation sites of influenza virus HA affect virus formation, and that inhibition of palmitylation of HA inhibits the formation of infectious influenza virus.
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