摘要 |
<p>A sanitary slider valve shown specifically as a rotary carousel diaphragm valve which has a thermoplastic elastomeric diaphragm (230) integrally molded to form the multiple sealing ports of the rotor/stator interface is described. Ports or grooves molded into the face of the elastomeric diaphragm are positioned to sealably engage grooves or ports in the stator face, and to form sanitary elastomeric tubular ducts leading through the body of the rotor or of the stator, terminating as elastomeric flanges. These flanges permit direct connection to sanitary flared piping flanges within the carousel which lead to and from multiple columns or other solid phase bed segments, or to sanitary flared piping flanges connecting the stator to piping interconnecting the multiple carousel columns to each other and to external supply and collection lines. Sanitary operation is made operable by energized flexible diaphragm wiping lip seals (222) which maintain fluid-tight sealing engagement with the opposing face even when the rotor (201) is lifted off the stator (300) far enough to permit cross flushing of the port sealing faces with sanitizing fluid. The valve permits sanitary operation of advanced chromatographic separations of biopharmaceuticals, including simulated moving bed chromatography.</p> |