| 摘要 |
A novel imidazole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, useful as excellent antihyperlipemic and antiarteriosclerotic, wherein R1 represents hydrogen or lower alkyl; n represents 0 or 1; X represents N-r1 (r1 representing hydrogen or lower alkyl), O, S, SO, SO2, CH2, CH(CH3), CONH or C(r2) = NO (r2 representing hydrogen or lower alkyl); m represents an integer of 0.1 to 12; and A represents methyl or a group represented by general formula (2) wherein Y represents N-r3 (r3 representing hydrogen or lower alkyl), N(r4)SO2 (r4 representing hydrogen or lower alkyl), O, S, SO, SO2, CH2, CH(CH3), CONH or C(r5) = NO(r5 representing hydrogen or lower alkyl); R2 represents halogen, lower alkyl, lower alkoxy, cycloalkyl or COOr6 (r6 representing hydrogen or lower alkyl); and 1 represents 0, 1, 2 or 3; provided that m represents an integer of 6 to 9 when A is methyl, that m represents an integer of 0, 1 to 6 when A is a group of general formula (2) and that X and Y represent each CH2 when m is 0.
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