摘要 |
Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed. |
申请人 |
TRUSTEES OF DARTMOUTH COLLEGE;UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER;NOELLE, RANDOLPH, J.;DURIE, FIONA, H.;PARKER, DAVID, C.;APPEL, MICHAEL, C.;PHILIPS, NANCY, E.;MORDES, JOHN, P.;GRENIER, DALE, L.;ROSSINI, ALDO, A. |
发明人 |
NOELLE, RANDOLPH, J.;DURIE, FIONA, H.;PARKER, DAVID, C.;APPEL, MICHAEL, C.;PHILIPS, NANCY, E.;MORDES, JOHN, P.;GRENIER, DALE, L.;ROSSINI, ALDO, A. |