发明名称 |
NEW CYCLOPROPYL DERIVATIVES, PREPARATION METHOD THEREOF AND APPLICATIONS. |
摘要 |
<p>The new cyclopropyl derivatives have formula (I) wherein R is cyclopropyl or methylcyclopropyl. The preparation process comprises reacting 2,6-dibromohexanoyl chloride with 2,6-dimethylanyline in the presence of a base at 0 DEG -25 DEG C to give 2,6-dibromohexanoyl-2,6-dimethylanilide which subsequently is caused to react with R-NH2 (wherein R is as defined hereabove) at 70-100 DEG C to give the cyclopropyl derivatives having formula (I). The compounds (I) can be applied as antiarithmic agents and as local anaesthetic agents. <CHEM></p> |
申请公布号 |
EP0677514(A1) |
申请公布日期 |
1995.10.18 |
申请号 |
EP19940931597 |
申请日期 |
1994.11.03 |
申请人 |
INSTITUTO DE INVESTIGACION Y DESARROLLO QUIMICO-BIOLOGICO S.A. |
发明人 |
VERDE CASANOVA, MARIA JOSE;GALIANO RAMOS, ALVARO |
分类号 |
C07D211/34;A61K31/00;A61K31/445;A61K31/4458;A61K31/4465;A61K31/451;A61P9/06;A61P23/00;A61P23/02;A61P25/02;C07D211/60;(IPC1-7):C07D211/34 |
主分类号 |
C07D211/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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