摘要 |
Compounds of formula (I): <IMG> (I) ¢in which: either (a) the dotted line (---) is a single bond; A= is oxygen; and B is a group of formula (II): <IMG> (II) (in which m is 0 and n is 0 or 1) or (b) the dotted line (---) is a double bond; A= is said group of formula (II) in which m is 1 and n is 0 or l; and B is absent; and R1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, optionally substituted benzyl or optionally substituted phenyl; R2 is hydrogen, halogen, alkyl, optionally substituted phenyl or heterocyclic or R1 and R2, together with the carbon atoms to which they are attached, are a hydrocarbon ring fused to the isoxazole ring; R3 and R4 are each hydrogen, alkyl, optionally substituted benzyl or optionally substituted phenyl; or R3, R4 and the nitrogen atom to which they are attached together represent an alicyclic amino group!; and salts thereof may be used for the treatment of cerebral circulatory problems and for use as centrally acting muscle relaxants.
|
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
NAGANO, MITSUO;SAKAI, JUNICHI;IWATA, NOBUTOSHI;KOBAYASHI, KAZUO;KOZUKA, MASAO;KATO, KATSUNORI;YOSHIMI, KENJI;KUBO, YOSHIKO |