The invention relates to humanized milk. The milk is produced by a non-human transgenic mammal wherein the genome of said transgenic non-human mammal contains at least one heterologous gene encoding for a human catalytic entity and wherein the catalytic entity produces oligosaccharides and glycoconjugates that are present in the milk of said transgenic non-human mammal. An especially useful catalytic entity is human glycosyltransferases which produce oligosaccharides and glycoconjugates. A method of obtaining humanized milk is disclosed. The method comprises the steps of (a) inserting into the genome of a non-human mammal a heterologous gene encoding the production of a human catalytic entity wherein said catalytic entity produces a secondary gene product in the milk of said non-human mammal; and (b) milking said non-human mammal. The humanized milk may be used in the preparation of an enteral nutritional product useful in the nutritive maintenance of an animal.
申请公布号
CA2184687(A1)
申请公布日期
1995.09.14
申请号
CA19952184687
申请日期
1995.01.24
申请人
ABBOTT LABORATORIES;OHIO UNIVERSITY;UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
发明人
PRIETO, PEDRO ANTONIO;SMITH, DAVID FLETCHER;CUMMINGS, RICHARD DALE;KOPCHIK, JOHN JOSEPH;MUKERJI, PRADIP;MOREMEN, KELLEY WILSON;PIERCE, JAMES MICHAEL