NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS

摘要

A compound of formula (I) wherein, R<1> is carboxy or protected carboxy; R<2> is hydrogen, hydroxy or protected hydroxy; R<3> is hydrogen, hydroxy, protected hydroxy, etc.; R<4> is hydrogen or halogen; A<1> is lower alkylene; A<2> is bond or lower alkylene; -R<5> is (a) (in which R<6> is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc.; and (b) is (c), etc.; and a pharmaceutically acceptable salt thereof which are useful as medicaments.