发明名称 |
Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones |
摘要 |
A method for the enantioselective reduction of an alpha -iminoketone to an alpha -aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole as the catalyst. The method is applied to the synthesis of R-albuterol from methyl 5-acetylsalicylate in high yield and high optical purity.
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申请公布号 |
US5442118(A) |
申请公布日期 |
1995.08.15 |
申请号 |
US19940231231 |
申请日期 |
1994.04.22 |
申请人 |
SEPRACOR, INC. |
发明人 |
GAO, YUN;HONG, YAPING;ZEPP, CHARLES M. |
分类号 |
B01J31/22;C07B53/00;C07B61/00;C07C213/00;C07C213/02;C07C215/60;C07F5/02;(IPC1-7):C07C213/00 |
主分类号 |
B01J31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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