发明名称 |
PROCESS FOR SOLID PHASE GLYCOPEPTIDE SYNTHESIS |
摘要 |
A process for the synthesis of a glycopeptide using a solid phase matrix is disclosed. The matrix is compatible with aqueous and organic solvents and is comprised of a silica-based solid support to which is linked a two-part spacer group having a chain length of about 12 to about 40 methylene groups. The first part of the spacer is covalently bonded to the silica-based support and has a length of about 3 to about 10 methylene groups. The second spacer part is covalently bonded to the first part of the spacer and comprises the distal end of the two-part spacer. The second part is soluble as a free molecule in each of water, dimethylformamide and dichloromethane and has a terminal amine or hydroxyl group to which the C-terminal residue of the peptide portion of the glycopeptide chain is bonded. The chain of atoms connecting the desired glycopeptide to the solid phase matrix also includes a moiety having a selectively severable bond which on cleavage of that bond separates the matrix from whatever else is bonded to that moiety.
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申请公布号 |
WO9521262(A1) |
申请公布日期 |
1995.08.10 |
申请号 |
WO1994US12841 |
申请日期 |
1994.11.08 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
WONG, CHI-HUEY;SCHUSTER, MATTHIAS |
分类号 |
C07K1/04;(IPC1-7):C12P21/00 |
主分类号 |
C07K1/04 |
代理机构 |
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主权项 |
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地址 |
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