| 摘要 |
NEW MATERIAL:The title substances of formula I: (X is alkyl, alkoxy, H, halogen, sulfamoyl, cyano group, etc,. R1 is H or lower alkyl group; R2 is lower alkyl group; n is 0 or an integen 1-3; R3 is aryl, bonzdioxane, aryloxy group, etc.). EXAMPLE:5-{1-dydroxy-2-[1-(1,4-benzioxane-2-yl) ethylamomp] ethyl}-2-methoxybenzenesulfonamide. USE:Hypotensius, treatmetns for peripheral failure and angina pectioris. PROCESS:Halohydrins of formula II or epoxides of formula III are reacted with amines of formula IV to give the compounds of formula I. Allernatively, aminoketones of formula V: (Z is H or benzyl group) are reduced, and when Z is benzyl group it is removed. The compounds of formula IV include novel ones. |
