发明名称 METHOD FOR PRODUCING 1-HYDROXYINDOLES
摘要 <p>PURPOSE:To easily obtain a 1-hydroxyindole by protecting the OH group of a 1-hydroxy-2-oxyindole as a raw material, reducing the reaction product, introducing a prescribed substituent to the reduction product, and finally removing the protecting group through a partially new intermediates. CONSTITUTION:A 1-hydroxy-2-oxyindole of formula I [the ring A is (substituted) benzene] is reacted with a compound of formula: HOCH2CH2-R (R is pyridyl, 2-trialkylsilyl) to obtain a 1-O-substituted oxyindole of formula II in which the OH is protected). The compound is reduced to obtain a 1-O-substituted indole of formula III. A substituent is introduced into the 3-position of the obtained 1-O-substituted indole. The protecting group is finally removed from the obtained compound of formula IV to obtain a 1-hydroxyindole of formula V. The 1-O-substituted-2-oxyindole of formula VI and the 1-O-substituted indole of formula VII are new among the intermediates obtained by the reactions.</p>
申请公布号 JPH07196609(A) 申请公布日期 1995.08.01
申请号 JP19930354280 申请日期 1993.12.28
申请人 KIKUKAWA YASUO 发明人 KIKUKAWA YASUO
分类号 C07D209/08;C07D209/12;C07D209/14;C07D209/42;(IPC1-7):C07D209/12 主分类号 C07D209/08
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