发明名称 |
TREATMENT FOR JUVENILE DIABETES |
摘要 |
A method for treating diabetes mellitus by administering composition providing a gastrin/CCK receptor ligand, e.g. a gastrin, and an EGP receptor ligand, e.g. TGF.alpha., in an amount sufficient to effect differentiation of pancreatic islet precursor cells to mature insulin-secreting cells. The composition can be administered systemically or expressed in situ by cells transgenically supplemented with one or both of a gastrin/CCK receptor ligand gene, e.g. a preprogastrin peptide precursor gene and an EGF receptor ligand gene, e.g. a TGF.alpha. gene.
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申请公布号 |
CA2182034(A1) |
申请公布日期 |
1995.07.27 |
申请号 |
CA19942182034 |
申请日期 |
1994.01.24 |
申请人 |
RESEARCH TRIANGLE PHARMACEUTICALS LTD.;GEN HOSPITAL CORP |
发明人 |
NARDI, RONALD V.;BRAND, STEPHEN J. |
分类号 |
A01K67/027;A61K35/39;A61K38/00;A61K38/16;A61K38/18;A61K38/22;A61K38/27;A61K38/43;A61K48/00;A61P5/48;C07H21/04;C12N15/09;C12N15/85;(IPC1-7):A61K38/22 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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