摘要 |
Compounds of formula (I): <IMAGE> (I) wherein R1 is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulfonyl, haloalkanesulfonyl or sulfamoyl; R2 is 5,6-dihydro-1,4,2-dioxazin-3-yl; R3 is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is -NH- or oxygen or sulfur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.
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申请人 |
SANKYO COMPANY, LIMITED;UBE INDUSTRIES LIMITED |
发明人 |
KOIKE, HIROYUKI;ASAI, FUMITOSHI;SUGIDACHI, ATSUHIRO;KIMURA, TOMIO;INOUE, TERUHIKO;NISHINO, SHIGEYOSHI;TSUZAKI, YASUNORI |