MORPHINAN DERIVATIVE AND MEDICINAL USE.

摘要

A morphinan derivative represented by formula (1) or a pharmacologically acceptable acid-addition salt thereof, and analgesic, diuretic, antitussive and brain cell protective agents each containing the derivative or the salt as the active ingredient. These compounds have potent analgesic, diuretic and antitussive effects as a highly selective kappa -opioid agonist, and are useful as analgesic, diuretic and antitussive agents. In addition, they have a significant brain cell protective effect and are useful as a brain cell protective agent. <CHEM>