发明名称 |
2'-ALKYLIDEN-PYRIMIDIN-NUKLEOSID-DERIVATE, VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG. |
摘要 |
<p>pyrimidine nucleosides of formula (I) and their salts are new: where R1 is amino or OH; R2 is H, halogen or lower alkyl; R3 is H or lower alkyl; R4 is H or a phosphate residue. Preferred are (I) where R3=H, and especially where R3=H and R2 is H, halogen or Me. Most preferred are (I) where R2=R3=H and R1 is amino; and where R1=OH, R2=Me and R3=H. (I) are prepd. from cpds. (II) where Z is a hydroxyl-protecting group; R5 is alkoxy, OH, amino or acylamino) by Wittig alkylidenation using for example Ph3P=CHR3, followed by removal of protecting groups and opt. phosphorylation.</p> |
申请公布号 |
AT124702(T) |
申请公布日期 |
1995.07.15 |
申请号 |
AT19880902560T |
申请日期 |
1988.03.17 |
申请人 |
YAMASA SHOYU KABUSHIKI KAISHA |
发明人 |
MATSUDA, AKIRA MINAMISHINKAWA KOUMUIN;MONBUSHO-YOUCHI, NISHI 13-CHOME, KITA;UEDA, TORU;TAKENUKI, KENJI;MACHIDA, HARUHIKO |
分类号 |
C07H19/06;(IPC1-7):C07H19/06;A61K31/70;C07H19/067 |
主分类号 |
C07H19/06 |
代理机构 |
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地址 |
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