| 摘要 |
[N,N'-bis(2-hydroxybenzyl)ethylenediamine N,N'-diacetic acid] derivatives of formula (I) in which R represents -(CO)-R1, -O-(CO)-R2, -O-(CO)-O-R3 or (a) wherein R1 is -NR4R5 or (III); whereby R4 and R5 are independent of each other C1-C3 alkyl or C3-C7 cycloalkyl or form together the group -(CH2)n-, n is an integer from 3 to 6; R2 is C1-C6 alkyl, unsubstituted phenyl or phenyl substituted by one to four substituents selected from the group consisting of halogen and hydroxy; R3 is C1-C6 alkyl or C3-C7 cycloalkyl; R4 is C1-C3 alkyl; and salts thereof form chelate-type metal complexes with trivalent metal ions, especially iron (III), and can be used, for example, for the treatment of pathological conditions in warm-blooded animals that are associated with an excess of trivalent metal ions in the body. |
