| 摘要 |
<p>The invention relates to an indole derivative of formula (I), wherein R1 and R2 independently represent hydroxy, methoxy or fluorine, preferably hydroxy; n represents an integer of 9 to 12; and X represents a member of the group consisting of CONR4R5, CSNR4R5, NR4COR5, NR4R5, SO2NR4R5, NR4SO2R5, 1-R4-5-tetrazole, wherein R4 and R5 are independently selected from the group of hydrogen and lower alkyls or R4 and R5 together form a bridge of the formula -(CH2)y- wherein y represents an integer 4 or 5, are disclosed. The invention also relates to a pharmaceutical preparation comprising one or more of said indole derivatives and to the use of said derivatives as a medicament are described. Also disclosed is the use of said indole derivatives for the preparation of a medicament for the therapeutic or prophylactic treatment of an estrogen related disorder or disease, such as in estrogen replacement therapy and/or breast cancer.</p> |
