| 摘要 |
Methods for controlling genomic and nongenomic cellular responses which are mediated by 1.alpha.,25-(OH)2 vitamin D3¢1.alpha.,25-(OH)2D3!. The method involves treating cells which exhibit nongenomic responses to 1.alpha.,25 (OH)2D3 with the vitamin C3 analogues 1,25(OH)2-previtamin D3 or 1.beta.,25 (OH)2 vitamin D3 ¢1.beta.,25-(OH)2D3!. The 1,25(OH)2-previtamin D3 functions as an agonist to promote the cellular response while the 1.beta.,25-(OH)2D3 functions as an antagonist. Transcaltachia is one of the nongenomic responses which is affected and can be controlled by administration of 1,25(OH)2previtamin D3 or 1.beta.,25-(OH)2D3. Fifteen additional analogues are disclosed which may be used to control genomic and/or nongenomic cellular responses.
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