摘要 |
The known processes for the preparation of homochiral amino alcohols of the formula I <IMAGE> wherein R<1>, R<2>, R<3> and <*> have the meaning indicated in the description, by reaction of the corresponding acid with organometallic compounds are either laborious, or afford a low yield or alternatively only low enantiomer purity. The novel process is intended to avoid these disadvantages. According to the invention, N-silylated amino acid silyl esters of the formula II <IMAGE> wherein R<1>, R<2>, R<4> and <*> have the meaning indicated in the description, are reacted with organometallic compounds, in particular Grignard reagents, in high yield and enantiomer purity. Chiral catalysts in the enantioselective reduction of assymetric ketones. |