| 摘要 |
<p>PURPOSE: To obtain a 3-aryl-2-hydroxypropionic acid derivative useful as a hypoglycermic agent and a blood cholesterol lowering agent. CONSTITUTION: This compound is represented by formula I A is represented by formulae II to IV [(n) is 0 or 1]; R<1> is a 1-8C alkyl, a 3-7C cycloalkyl, a 3-8C alkenyl, a 3-8C alkynyl, phenyl, a 7-8C phenylalkyl or a 2-8C alkanoyl; X is S, O or NR<2> (R<2> is H, a 1-3C alkyl, phenyl or benzyl), CH=CH, CH=N or N=CH; Y is CH or N; Z is H, a 1-7C alkyl, a 3-7C cycloalkyl or phenyl; X<1> is O, S, SO or SO2 ; Y1 is OH, a 1-3C alkoxy, phenoxy, benzyloxy, a 1-7C alkanoylamino, benzenesulfonylamino, etc.; Z<1> is H or a 1-3C alkyl}, e.g. 3-[2-((5- methyl-2-phenyl-4-oxazolyl)methyl)benzofuran-5-yl]-2-(propylthio)propa noic acid.</p> |
