摘要 |
The present invention is related to substituted pyrazolyl benzenesulfonamides of the Formula I (see formula I) wherein R2 is selected from hydrido, C1-C10-alkyl, C1-C6-haloalkyl, C1-C6-alkoxycarbonyl, cyano, carboxyl, C1-C6-cyanoalkyl, aminocarbonyl, C1-C6-alkylaminocarbonyl, C3-C7-cycloalkylaminocarbonyl, arylaminocarbonyl, C1-C6-carboxyalkylaminocarbonyl, aryl-C1-C6- alkoxycarbonyl-C1-C10-alkylaminocarbonyl, C1-C6-aminocarbonylalkyl, C1-C6-carboxyalkyl, C1-C6-alkoxycarbonylcyano-C2-C6-alkenyl and C1-C6-hydroxyalkyl; wherein R3 is selected from hydrido, C1-C10-alkyl, cyano, C1-C6-hydroxyalkyl, C3-C7-cycloalkyl, C1-C6-alkylsulfonyl, and halo; and wherein R4 is selected from optionally substituted C3-C10-cycloalkyl, C3-C10-cycloalkenyl and heterocyclic; provided R2 and R3 are not both hydrido, further provided that R4 is not triazolyl when R2 is methyl; and further provided that R4 is not substituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof. The invention is also related to pharmaceutical compositions containing such compounds.
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申请人 |
G.D. SEARLE & CO. |
发明人 |
GRANETO, MATTHEW J.;ROGERS, ROLAND S.;CARTER, JEFFERY S.;DOCTER, STEPHEN H.;YU, STELLA S.;BERTENSHAW, STEPHEN R.;TALLEY, JOHN J.;MIYASHIRO, JULIE M.;MALECHA, JAMES W.;COLLINS, PAUL W.;ROGIER, DONALD J., JR.;PENNING, THOMAS D.;KHANNA, ISH K. |