Process for the preparation of 2-substituted 5-alkyl-pyridines

摘要

The title compounds of the formula <IMAGE> (I) can be prepared by cyclization of aminomethylenated 2-pentenoic acid derivatives of the formula <IMAGE> (II) where R, X, R1, R2 and Z have the meaning given in the description, in the presence of acids or ammonia. Preferably, aminomethylenated pentenoic acid derivatives are employed which can be prepared from pentenoic acid derivatives of the formula R-CH2-CH2-CH=CH-Z(III) or R-CH2-CH=CH-CH2-Z(IV) with ortho-amides of the formula <IMAGE> (V) The meanings of A and B are also given in the description.