Intermediates for the preparation of heteroaryl derivatives of monocyclic beta-lactam antiobiotics

摘要

Antibacterial activity is exhibited by novel compounds having the formula <IMAGE> 1 where R1, R2, and M are as defined herein and X is -(CH2)n- wherein n is 0, 1, 2, 3 or 4 or CR3R4 wherein R3 and R4 are the same or different and each is hydrogen, -CH3 or -C2H5 or R3 and R4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring. Also described are various intermediates for the preparation of compounds of formula 1.